Neuroimaging technique identifies concussion-related brain disease in living brain.

Do you want to know more about tauopathy PET imaging techniques in living patients? Neuroimaging technique identifies concussion-related brain disease in living brain. Thoughts health innovators? bit.ly/1wpA7J0

Neuroimaging technique identifies concussion-related brain disease in living brain - featured image - neuroinnovations

An experimental positron emission tomography (PET) tracer is effective in diagnosing concussion-related brain disease while a person is still alive, according to a case study conducted at the Icahn School of Medicine at Mount Sinai, and at Molecular Neuroimaging (MNI) LLC, and published in the journal Translational Psychiatry.

Specifically, the study results suggest that an experimental…

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A*STAR scientists link zebrafish genes to human respiratory diseases.

A*STAR scientists link zebrafish genes to human respiratory diseases. Thoughts health innovators? bit.ly/1r0Hsg6

Human airway cells produce hundreds of motile cilia. Cilia are labelled in green, cell membranes in red, and nuclei in blue.  Copyright 2009 Agency for Science, Technology and Research.

A small freshwater fish found in many tropical aquariums may hold the key to unlocking one of the leading causes of respiratory diseases in humans.

Scientists from A*STAR’s Institute of Molecular and Cell Biology (IMCB) have identified hundreds of novel genes in the zebrafish that could be functionally identical to the human genes required for forming motile cilia, hair-like structures on the…

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Scientists begin to map neurodevelopment of schizophrenia.

Scientists begin to map neurodevelopment of Schizophrenia. Thoughts health innovators? bit.ly/1BLql6V

Abnormalities of growth curves in childhood-onset schizophrenia (COS) for each of the ~80,000 cortical vertices, using penalized spline models and false discovery rate (FDR)-adjusted p values. (A) Cortical regions with any difference in the maturational trajectory in COS, either a constant trait difference or an age-varying trajectory difference. In other words, the null hypothesis H0, that βv (age) in equation (2) is identically zero, is rejected. (B) Regions for which the null hypothesis H0a that Math Eq in equation (3) is rejected. All of these regions are, in fact, thinner in COS. The plot below shows the average maturational trajectory of these regions with 95% confidence intervals. (C) Regions with significant group differences in trajectory, i.e., the null hypothesis H0b that Math Eq is identically zero in equation (3) is rejected. The plot below shows the average maturational trajectory of these regions with 95% confidence intervals.  Abnormal Cortical Growth in Schizophrenia Targets Normative Modules of Synchronized Development.  Alexander-Bloch et al 2014.

Schizophrenia is generally considered to be a disorder of brain development and it shares many risk factors, both genetic and environmental, with other neurodevelopmental disorders such as autism and intellectual disability.  The normal path for brain development is determined by the combined effects of a complex network of genes and a wide range of environmental factors.

However, longitudinal…

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Protein appears to protect against bone loss in arthritis.

Protein appears to protect against bone loss in arthritis. Thoughts health innovators? bit.ly/1t68l4v

Protein appears to protect against bone loss in arthritis - featured image - healthinnovations

A small protein named GILZ appears to protect against the bone loss that often accompanies arthritis and its treatment, researchers from the Georgia Regents University report.

Arthritis as well as aging prompt the body to make more fat than bone, and the researchers have previously shown GILZ can restore a more youthful, healthy mix. It also tamps down inflammation, a major factor in arthritis. …

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Using fluorescent markers they observed tumour growth using time-lapse microscopy. Cells in G1-phase are red and stay red if arrested; growing zones go through the cell cycle and exhibit red, yellow and green cells representing all cell cycle phases. Cells in the centre of the tumour rapidly become dormant (red), while cells in the periphery and invading cells continue to divide (changing colours). 
Credit:  Dr Fiona McMillan

Using fluorescent markers they observed tumour growth using time-lapse microscopy. Cells in G1-phase are red and stay red if arrested; growing zones go through the cell cycle and exhibit red, yellow and green cells representing all cell cycle phases. Cells in the centre of the tumour rapidly become dormant (red), while cells in the periphery and invading cells continue to divide (changing colours).

Credit:  Dr Fiona McMillan

Researchers make scientific history with new cellular connection.

Researchers make scientific history with new cellular connection. Thoughts health innovators? bit.ly/1pcLOwI

In normal cells, such as the image on the left, a piece of the Fat protein is processed and delivered into the mitochondria where it influences the energy status of the cell. In mutated cells, this particular component is missing, causing the energy generating pipeline inside mitochondria to become destabilized, and leading to loss of energy production.  Credit:  Dr. Helen McNeill, Lunenfeld-Tanenbaum Research Institute.
Researchers from the Lunenfeld-Tanenbaum Research Institute have revealed an exciting and unusual biochemical connection. Their discovery has implications for diseases linked to mitochondria, which are the primary sources of energy production within our cells. The team has an international reputation for their work in understanding how cells become organized into tissues and how growth is…

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